(E. faecium M74®, L. paracasei F19®, Bif. Bifidum, L. acidophilus, L. casei) Probiotic Blends TM Maximum Defense TM Probiotic Strains
Aside from the many claimed benefits of probiotic bacteria such as Bifidobacteria Bifidum, L. acidophilus, and, L. casei. we would would like to point to specific research and documentation of our E. faecium M74® L. paracasei F19®.
E. faecium M74®
Quote from article: Beneficial modification of the human intestinal microflora using orally administered lactic acid bacteria by Ferencik M, Ebringer L, Mikes Z, Jahnova E, Ciznar I. “Lactic acid bacteria in food can transiently colonize the intestine and exert health beneficial (probiotic) effects. These include: 1. Lactose digestion, improvement of diarrheal disorders (including traveler’s diarrhea), prophylaxis of intestinal and urogenital infections – as a result of formation or reconstruction of a balanced indigenous microflora. 2. Inhibition of the mutagenicity of the intestinal contents and reduction of the incidence of intestinal tumors. 3. Immunomodulatory effects resulting in the improved host resistance. 4. Depression of serum cholesterol level. The most of these effects were observed in a group of adult subjects administered daily…. E. faecium M74®.
Quote from study: One-year application of probiotic strain E. faecium M74® decreases serum cholesterol levels by Hlivak P, Odraska J, Ferencik M, Ebringer L, Jahnova E, Mikes Z. “Conclusions: In our study, the administration of E. faecium M74® probiotic strain was associated with reduction of serum cholesterol concentration by 12%(Primarily LDL(bad cholesterol) after 56 weeks.”
o E. faecium M74® found in stool 6 weeks after last dose given(shows it’s strong ability to colonize).
o E. faecium M74® showed the ability to reduce the average activity of beta-D-glucuronidase which is, an enzyme produced by colonic microflora and involved in Phase II liver detoxification. Elevated beta-D-glucuronidase activity is associated with an increased risk for various cancers, particularly hormone-dependent cancers such as breast, prostate, and colon cancers.
o May have a significant immunostimulatory effect on both phagocytosis performed by neutrophils and antibody production.
o Defend against pathogens and infections by:
1.Production of acid(mainly lactic acid) creating a low ph environment
2.Production of antimicrobial substances
3.Anti-enterotoxic activity against enterotoxins
o Ability to adhere to intestinal walls(competitive exclusion)
o Produces mainly the L-isomer of lactic acid (has been shown to inhibit the growth of germs more effectively than the D-isomer)
o Short generation time (multiplies every 18-20 min) allows it to out compete other slower multiplying bacteria
o E. faecium M74® has the ability to tolerate high temperatures(it has been shown to survive for 6 minutes at temperatures exceeding 161 degrees F.)
o Health & Safety – This strain is considered non-toxic and harmless to humans and animals. It leaves no residues and has no withdrawal time. This product is considered GRAS(Generally recognized as safe) by the US FDA
L. paracasei F19®
o Well tolerated by infants, adults and elderly persons.
o Adheres to the colon and it increases the level of LAB in the GI-microflora.
o It has been shown to increase the L-lactic acid as well as short chain fatty acids in the colon.
o Ferments most common simple carbohydrates including a number of such carbohydrates of special importance in dairy products as lactose, galactose, inulin and tagatose
o During 12 week study, the strain could be reisolated even eight weeks after the intake of the strain had ended.(shows it’s strong ability to colonize).
o When tested in a TNO-model(simulation of conditions in the stomach and small intestines) on average 240% more Lactobacillus F19® were shown to pass through the stomach than the other Lactobacillus species tested.
o When tested in a SHIME Reactor (imitation of human intestines) Lactobacillus F19® changed the microenvironment by increasing the concentration of L lactic acid and total short-chain fatty acids by 50 to 100%
o Tolerates high levels of human bile
o A research study listed in the journal MICROBIAL ECOLOGY in Health and Disease Supplement 3/2002 - Lactobacillus F-19®(Lactobacillus paracasei - F19®) – Closing the Broken Circle states: There was a tendency for higher frequencies of stools and less hardness of stools in the treatment group….. without increase in flatulence.
o Produces mainly the L-isomer of lactic acid (has been shown to inhibit the growth of germs more effectively than the D-isomer)
Bifidobacterium bifidum
Bifidobacteria are normal inhabitants of the human and animal colon. Newborns, especially those that are breast-fed, are colonized with bifidobacteria within days after birth. Bifidobacteria were first isolated from the feces of breast-fed infants. The population of these bacteria in the colon appears to be relatively stable until advanced age when it appears to decline. The bifidobacteria population is influenced by a number of factors, including diet, antibiotics and stress. Bifidobacteria are gram-positive anaerobes. They are non-motile, non-spore forming and catalase-negative. They have various shapes, including short, curved rods, club-shaped rods and bifurcated Y-shaped rods. Their name is derived from the observation that they often exist in a Y-shaped or bifid form. The guanine and cytosine content of their DNA is between 54 mol% and 67mol%. They are saccharolytic organisms that produce acetic and lactic acids without generation of CO2, except during degradation of gluconate. They are also classified as lactic acid bacteria (LAB). To date, 30 species of bifidobacteria have been isolated. Bifidobacteria used as probiotics include Bifidobacterium bifidum.
Lactobacillus Acidophilus or L. acidophilus
Lactobacillus Acidophilus is the predominant friendly bacteria in the upper intestinal tract. Lactobacillus is the general (genus) name of the bacteria, Acidophilus is the particular strain. It helps reduce the levels of harmful bacteria and yeasts in the small intestine and also produces lactase, an enzyme which is important in the digestion of milk. L. Acidophilus is also involved in the production of B vitamins (niacin, folic acid, and pyridoxine) during the digestive process.
Not only can Acidophilus and other probiotics tune up your intestinal function, counteract antibiotic damage, and stimulate the immune system to function better when you’re relatively well, but when you’re ill, they can also contribute significantly to relief of health problems ranging from indigestion and diarrhea to colon and liver cancer.
Lactobacillus Casei or L. Casei
This genus of lactobacillus is documented to have a wide pH and temperature range, and complements the growth of lactobacillus acidophilus. It also produces DL-lactic acid and amylase. Of all the strains of lactobacillus that are available including acidophilus, two strains stand out as exceptional stimulators of Th1 cytokines. They are L-Casei and L. Plantarum. Both strains of intestinal flora strongly increase Il-12 production along with gamma interferon thus increasing CD8 cytotoxic lymphocyte activity against most kinds of intracellular viral infections.
L. Casei - induces IL-12, IL-2 & IFN-gamma - suppresses IL(4,5,6 and 10) anti(viral & bacterial), anti-cancer effects
Japan: Matsuzaki T has found that in mice given the Lactobacillus Casei strain, that it induced the production of several cytokines including IFN-gamma, IL-beta and TNF-alpha, resulting in the inhibition of tumor growth and chemically-induced bladder cancer. Matsuzaki states that L. Casei
“has the potential to ameliorate or prevent a variety of diseases through modulation of the host’s immune system, specifically cellular immune responses.”(1)
Other Japanese researchers, Kato, Endo and Yokojura found that at a dose of 100 to 200 mg/kg/day of L. Casei for 7 days, implanted tumor growth was suppressed, but not in the control mice who did not receive this strain of lactobacillus. In this experiment, live L. Casei, rather that heat-treated, was used. (2)
L. Casei or B. animalis inhibit Candida Albicans
Research from the University of Wisconsin by Wagner Rd et al has shown that L. Casei and Bifidobacterium animalis (B animalis) significantly reduced candida albican colonization in the intestines of immune deficient mice.
References:
1. Int J Food Microbiol 1998 May 26;41(2):133-40
2. Int J Immunopharmacol 1994 Jan;16(1):29-36
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